Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy
نویسندگان
چکیده
منابع مشابه
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy
G protein-coupled receptor (GPCR) signaling, mediated by hetero-trimeric G proteins, can be differentially controlled by agonists. At a molecular level, this is thought to occur principally via stabilization of distinct receptor conformations by individual ligands. These distinct conformations control subsequent recruitment of transducer and effector proteins. Here, we report that ligand effica...
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ژورنال
عنوان ژورنال: Cell
سال: 2016
ISSN: 0092-8674
DOI: 10.1016/j.cell.2016.09.021